The Effect of Hemodiafiltration on Inflammatory Biomarkers in Comparison to High Flux Dialyzers in Prevalent Hemodialysis Patients

Abstract Introduction Inflammation in patients with ESRD undergoing HD is an increasing concern for physicians and has been related to increase the rates of morbidity mortality. Interestingly, conventional have frequent infections a suboptimal response vaccines; this probably immune inflammatory disorder associated either uremia and/or nutritional status. In addition CRP, which seems be most important marker identification control inflammation clinical practice, many other markers are also available evaluation state. Decreased renal clearance clearly accounts higher levels circulating cytokines, although increased production described. Hemodiafiltration shown improve cardio-protection immunologic system reduces infection mortality compared HD. A recent study showed that hemodiafiltration reduced risk patients. Analysis pooled individual participant data from randomized controlled trials survival benefits high volume-HDF on all-cause especially cardiovascular rate. The mechanisms lead improved outcomes not clear, but it thought HDF may reduce mediators through use biocompatible dialysers ultrapure dialysate larger molecular weight substances, oxidative stress, endothelial dysfunction. Objective aim detect, prospectively, effect 3 months dialysis biomarkers comparison flux dialyzer stable Patients methods 30 adults aged 20-75 years who were selected Dialysis Unit, Kobary El-Kobba Military Hospital. male known chronic kidney disease more than divided into 2 groups:15 shifted 15 continued Regular Hemodialysis dialyzer. Full medical history examination. Anthropometric measurements Laboratory investigations including Complete Blood Picture (WBCs, platelets, Hb), Coagulation profile PT, PTT&INR, Liver function tests (ALT, AST, T. Bilirubin S. Albumin), Lipid (Triglycerides, total cholesterol, VLDL), creatinine, BUN, Na, K, Uric acid, Total Proteins, Serum Calcium, Phosphorus, PTH, ferritin, High sensitivity CRP (Enzyme- Linked Immunosorbent Assay (ELISA)) IL6 (ELISA). Results current was conducted regular dialysis. two groups representing (n = 15) group B 15). statistical significant difference (P < 0.01) found regarding K 4.3±0.6 meq/l while 5.2±0.5 B, phosphorus 4.6±1.0 mg/dl 6.1±0.9 no > 0.05) as regard uric acid. 63.5±40.9 73.4±33.2 85.3±37.6 156.7±151.9 after those before months. CRP. IL6. Conclusion present revealed there change hemodialysis decrease